6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one
| Hunhu hwemakemikari | 6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one imvura inoonekera isina ruvara kusvika yero yakajeka, isinganyungudike mumvura, inonyungudika muCHCl3, nzvimbo yekuchengetera inofanira kuomeswa nechando, yakaparadzaniswa nezvinhu zvinoodza muviri, makemikari anodyiwa, kure nemoto, uye kubva pakupisa. | |
| Mashandisirwo | 6-Bromo-7-methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-oneinhengo yeAlectinib, inhibitor ine simba uye inosarudza zvakanyanya ye lymphoma kinase (ALK) inokwanisa kudzivirira gatekeeper mutant isingapindi mishonga, izvo zvinoguma nekudzikira kwekukura kwemasero. | |
| Chimiro chemuviri | Mvura isina ruvara kusvika yero | |
| Nguva yesherufu | Zvichienderana neruzivo rwedu, chigadzirwa ichi chinogona kuchengetwa kwemaawa gumi nemaviri.mwedzi kubva pazuva rekuendeswa kana zvikachengetwa mumidziyo yakavharwa zvakasimba, zvakachengetedzwa kubva kuchiedza nekupisa uye zvakachengetwa patembiricha iri pakati pe5 -30°C. | |
| Thunhu hwemazuva ano
| Nzvimbo Yokubikira | 354.7±42.0 °C pa760 mmHg |
| Poindi yeFlash | 168.3±27.9 °C | |
| Misa chaiyo | 282.025543 | |
| PSA | 26.30000 | |
| LogP | 3.25 | |
| Kumanikidzwa kwemhepo | 0.0±0.8 mmHg pa25°C | |
| Indekisi yeKuramba | 1.545 | |
| pka | 1.26±0.10(Yakafanotaurwa) | |
| Kunyungudika Kwemvura | 50 mg/ml muCHCl3 | |
Kuchengetedzeka
Pakubata chigadzirwa ichi, ndapota tevedzera mazano neruzivo rwuri mupepa rekuchengetedza uye tevera matanho ekudzivirira uye ehutsanana panzvimbo yebasa akakodzera pakubata makemikari.
Cherechedza
Ruzivo rwuri muchinyorwa chino rwakavakirwa paruzivo rwedu rwemazuva ano uye ruzivo. Tichifunga nezvezvinhu zvakawanda zvinogona kukanganisa kugadziriswa nekushandiswa kwechigadzirwa chedu, ruzivo urwu harurerutsi vagadziri vezvigadzirwa kubva pakuita ongororo dzavo uye bvunzo; uye ruzivo urwu harurevi vimbiso yezvimwe zvinhu, kana kukodzera kwechigadzirwa kune chinangwa chaicho. Chero tsananguro, mifananidzo, mapikicha, data, zviyero, huremu, nezvimwewo zvakapihwa pano zvinogona kuchinja pasina ruzivo rwekare uye hazvirevi mhando yechibvumirano chechigadzirwa. Hunhu hwechibvumirano chechigadzirwa hunongobva chete pamashoko akanyorwa mutsanangudzo yechigadzirwa. Ibasa remugamuchiri wechigadzirwa chedu kuona kuti chero kodzero dzevaridzi uye mitemo iripo nemutemo zvinocherechedzwa.
