3 nzira dzinonakidza dzakagadzirwa nemakemikari gore rino
naBethany Halford
ENZYMES AKADZIDZWA AKAKABWA BIARYL BOND
Scheme inoratidza enzyme-catalyzed biaryl coupling.
Makemikari anoshandisa biaryl mamorekuru, ayo anoratidza mapoka earil akasungirirwa kune mumwe nemumwe nechisungo chimwe chete, sechiral ligands, zvivharo zvekuvaka, uye mishonga yemishonga.Asi kugadzira iyo biaryl motif nesimbi-catalyzed reactions, senge Suzuki neNegishi cross-couplings, zvinowanzoda akati wandei ekugadzira matanho ekugadzira vanobatana.Zvakare, aya masimbi-catalyzed reactions anodonha kana achigadzira bulky biaryls.Yakafuridzirwa nekugona kwema enzymes kukonzeresa maitiro, timu inotungamirwa neYunivhesiti yeMichigan's Alison RH Narayan yakashandisa yakatungamirwa shanduko kugadzira cytochrome P450 enzyme inovaka biaryl molecule kuburikidza neoxidative coupling yeanonhuwirira kabhoni-hydrogen zvisungo.Iyo enzyme inoroora mamorekuru anonhuhwirira kuti igadzire stereoisomer imwe yakatenderedza chisungo chine kutenderera kwakavharirwa (kuratidzwa).Vatsvakurudzi vanofunga kuti nzira iyi yebiocatalytic inogona kuva shanduko yechingwa-uye-bhota yekugadzira biaryl bond (Nature 2022, DOI: 10.1038/s41586-021-04365-7).
RECIPE FOR TERTIARY AMINES AKATENDERWA PAMUNYU MUNYAYA
Scheme inoratidza kuita kunoita tertiary amines kubva kune yechipiri.
Kusanganisa maelectron-hungry metal catalysts ane electron-rich amines anowanzo uraya zvinokonzeresa, saka mareagents esimbi haagone kushandiswa kuvaka tertiary amines kubva kune yechipiri amines.M. Christina White nevamwe vaaishanda navo paUniversity of Illinois Urbana-Champaign vakaona kuti vaigona kugadzirisa dambudziko iri kana vakawedzera munyu mukubika kwavo.Nekushandura maamines echipiri kuita ammonium munyu, vemakemikari vakawana kuti vaigona kuita izvi zvisanganiswa neterminal olefins, oxidant, uye palladium sulfoxide catalyst kugadzira makumi ezviuru epamusoro amines ane akasiyana emapoka anoshanda (muenzaniso wakaratidzwa).Vemakemikari vakashandisa maitiro ekugadzira mishonga inorwisa antipsychotic Abilify uye Semap uye kushandura zvinodhaka zviripo zviri zvechipiri mamines, senge antidepressant Prozac, kuita tertiary amines, zvichiratidza kuti vemakemikari vangagadzira sei mishonga mitsva kubva kune iripo (Science 2022, DOI: 10.1126/science.abn8382).
AZAARENES PASI CARBON CONTRACTION
Scheme inoratidza quinoline N-oxide yakashandurwa kuita N-acylindole.
Gore rino machemist akawedzera kune repertoire yemamorekuru editing, ari maitiro anoita shanduko kumacores emamorekuru akaomarara.Mune mumwe muenzaniso, vatsvakurudzi vakagadzira shanduko inoshandisa chiedza neasidhi kuti icheke kabhoni imwe kubva mumitezo mitanhatu azaarenes muquinoline N-oxides kuita N-acylindoles ine mhete dzine nhengo shanu (muenzaniso unoratidzwa).Kuita, kwakagadzirwa nenyanzvi dzekemesitiri muboka raMark D. Levin paYunivhesiti yeChicago, kwakavakirwa pakuita kwaibatanidza rambi remekiyuri, iro rinobudisa mafungu akawanda echiedza.Levin nevamwe vaaishanda navo vakawana kuti kushandisa mwenje-emitting diode inoburitsa mwenje pa390 nm kwakavapa kudzora kuri nani uye kwakavabvumira kuita reaction general yequinoline N-oxides.Kuita kutsva kunopa vanogadzira mamorekuru nzira yekugadziridza macores emakomisheni akaomarara uye inogona kubatsira vezvemishonga kutsvaga kuwedzera maraibhurari avo evanoda zvinodhaka (Science 2022, DOI: 10.1126/science.abo4282).
Nguva yekutumira: Zvita-19-2022