Nzira nhatu dzinonakidza dzakagadzirwa nevanochemist gore rino
naBethany Halford
Maenzyme Akashanduka Akavaka Zvisungo zveBiaryl
Chirongwa chinoratidza kubatana kwebiaryl kwakakamurwa ne enzyme.
Makemikari anoshandisa mamorekuru eBiaryl, ane maboka eAryl akabatana nechinhu chimwe chete, sechiral ligands, mabhuroko ekuvaka zvinhu, uye mishonga. Asi kugadzira biaryl motif nemetal-catalyzed reactions, senge Suzuki neNegishi cross-couplings, zvinowanzoda matanho akati wandei ekugadzira ma coupling partners. Uyezve, aya ma coupling-catalyzed reactions anokundikana pakugadzira bulky biaryls. Vachikurudzirwa nekugona kwema enzymes ku catalyzed reactions, timu inotungamirwa naAlison RH Narayan weYunivhesiti yeMichigan yakashandisa directed evolution kugadzira cytochrome P450 enzyme inovaka biaryl molecule kuburikidza ne oxidative coupling ye aromatic carbon-hydrogen bonds. Iyi enzyme inobatanidza aromatic molecules kuti igadzire stereoisomer imwe yakakomberedza chisungo chine kutenderera kwakavharirwa (kunoratidzwa). Vaongorori vanofunga kuti nzira iyi ye biocatalytic inogona kuva shanduko yechingwa nebhota pakugadzira biaryl bonds (Nature 2022, DOI: 10.1038/s41586-021-04365-7).
RESIPI YEKUDYA KWEMAHARA YAKASIMBISWA PAMUSORO PEMUNYU MUSHONGA
Chirongwa chinoratidza maitiro anoita maamine epamusoro kubva kune echipiri.
Kusanganisa ma catalyst esimbi anoda maerekitironi nema amine ane maerekitironi akawanda kunowanzouraya ma catalyst, saka ma reagents esimbi haagone kushandiswa kugadzira ma amine etaturi kubva kuma amine echipiri. M. Christina White nevamwe vake paYunivhesiti yeIllinois Urbana-Champaign vakaona kuti vaigona kukurira dambudziko iri kana vakaisa munyu mu resipi yavo ye reactant. Nekushandura ma amine echipiri kuita ammonium salts, ma chemist vakaona kuti vaigona kugadzirisa ma compounds aya ne terminal olefins, oxidant, uye palladium sulfoxide catalyst kugadzira ma amine akawanda etaturi ane mapoka akasiyana-siyana anoshanda (muenzaniso wakaratidzwa). Ma chemist akashandisa reaction iyi kugadzira mishonga yekurwisa pfungwa Abilify naSemap uye kushandura mishonga iripo iri ma amine echipiri, senge antidepressant Prozac, kuita ma amine etaturi, vachiratidza kuti ma chemist angagadzira sei mishonga mitsva kubva kune iripo (Science 2022, DOI: 10.1126/science.abn8382).
MaAzaarenes Akabvisa Kabhoni
Chirongwa chinoratidza quinoline N-oxide yakashandurwa kuita N-acylindole.
Gore rino masayendisiti emakemikari akawedzera muongororo yekuchinja kwemamorekuru, ayo ari maitiro anoita shanduko kumacore emamorekuru akaomarara. Mune mumwe muenzaniso, vaongorori vakagadzira shanduko inoshandisa chiedza neasidhi kubvisa kabhoni imwe chete kubva kumaazaarenes ane nhengo nhanhatu muquinoline N-oxides kuti vagadzire N-acylíndoles ine mhete dzine nhengo shanu (muenzaniso wakaratidzwa). Maitiro aya, akagadzirwa nemasayendisiti muboka raMark D. Levin paYunivhesiti yeChicago, akavakirwa pamaitiro aisanganisira rambi remercury, iro raiburitsa mawavelengths akawanda echiedza. Levin nevamwe vake vakaona kuti kushandisa diode inoburitsa chiedza inoburitsa chiedza pa390 nm kwakavapa kutonga kuri nani uye kwakavabvumira kuita kuti maitiro aya ave akajairika equinoline N-oxides. Maitiro aya matsva anopa vagadziri vemamorekuru nzira yekugadzirisa macore emacompounds akaomarara uye anogona kubatsira masayendisiti emishonga ari kutsvaga kuwedzera maraibhurari avo emishonga inoshandiswa (Science 2022, DOI: 10.1126/science.abo4282).
Nguva yekutumira: Zvita-19-2022